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A MyFibroTeam Member asked a question 💭
Limerick, PA

Does anyone take both? Does amitriptyline effect how Synthroid works? Any suggestions how to space them?

November 19, 2019
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Answer Summary

Members shared their experiences taking both Synthroid and amitriptyline, with the overwhelming consensus being that the two medications can... Read more

Members shared their experiences taking both Synthroid and amitriptyline, with the overwhelming consensus being that the two medications can be safely taken together without significant interactions. Several members offered practical spacing strategies, including taking Synthroid in the morning and amitriptyline in the evening, or when both must be taken at night, spacing them about two hours apart to avoid any potential interference with absorption. A recurring theme was confusion about how amitriptyline works, with members clarifying that it must be taken daily to build up in the system for pain or depression relief rather than on an as-needed basis, and that stopping it suddenly requires careful weaning under a doctor's guidance.

A MyFibroTeam Member

@A MyFibroTeam Member why would you only take Amitriptyline when your pain is really bad? It needs to be in your system to work properly. I hope your doctor didn’t prescribe it that way?

I copied and pasted this from a page about Amitriptyline

2. Key facts

Amitriptyline is widely used to treat depression, but at lower doses it's also very good for treating pain.
Amitriptyline can make you feel sleepy so it's best to take it in the evening or before you go to bed.
You may notice a difference after a week or two but it can take 6 weeks for amitriptyline to work as a painkiller.
Amitriptyline can cause extra side effects if you stop taking it suddenly. Talk to your doctor if you're thinking of stopping taking amitriptyline.

November 21, 2019
A MyFibroTeam Member

@A MyFibroTeam Member you are correct, amitriptyline should be taking daily, it’s an antidepressant.

November 21, 2019
A MyFibroTeam Member

I thought amitriptyline had to be taken on a regular basis in order to work, and once you’re on it I thought you had to wean yourself off it. I did not know it could be taken on an as needed basis.

November 20, 2019
A MyFibroTeam Member

I used to use amitriptyline and have been on synthroid for year. I didn't see any complications.

November 20, 2019
A MyFibroTeam Member

Thanks I have an Endo chronologist appointment coming up with a blood test so I’ll know definitely but wasn’t sure if anybody had the same experience.

November 20, 2019

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