Like she said above, it is different for everyone, but I can tell you what has worked & not worked for me.... I have been taking Zoloft for 20 years for depression & anxiety, but have gone off briefly a few times. Most recently I weaned off Zoloft to try Lyrica... bad, bad side effects after it built up in my system. So my doc switched me to Cymbalta, then to Effexor... same bad zombie-like effects with them all!! So, I went back to Zoloft & within two days started to feel "normal" again. That old saying applies, "if it ain't broke, don't fix it." I truly hope you find what works for you, it is pretty much trial & error. God bless. Susan

have you heard of kratom? it's a crap shoot with meds. some work great for some people. some are a nightmare. I've taken lots of treatments and still take prescribed meds but adding kratom has been a great experience.

@A MyFibroTeam Member That sounds so horrible, I do hope you found a much better treatment my dear. I am researching more of it right now as I am typing this, and I did as soon as I read your comment and the stories honestly scare me, I can only imagine the effects of this drug, since from what I read Lexapro gave me a preview of that. I still don't fully understand though why doctors insist on these pills when they could effect a person so badly. Thank you so much for your time and comment love!

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A MyFibro...

I was on Cymbalta for a year and a half. It only helped with my anxiety but stopped working so I weaned off. It was a NIGHTMARE getting off of it. Please read all the side effects....also Google "Cymbalta ruined my life" some really scary stories about this toxic drug

I take Cymbalta,Desperamine and Norco so far it does help except when I get a flare. But it is a trial and error kind of thing. Lyrica did not help me. But the Desperamine helps with sleep and depression. I changed my pain med. recently because I guess taking the same one for a long time does not work as good.