Answer Summary

Members overwhelmingly confirmed significant weight gain on Lyrica, Cymbalta, and Amitriptyline, with many reporting 30 to 50 pounds gained... Read more

Members overwhelmingly confirmed significant weight gain on Lyrica, Cymbalta, and Amitriptyline, with many reporting 30 to 50 pounds gained despite healthy eating and regular exercise, and frustration that the weight remains stubbornly resistant to traditional diet and fitness efforts. Several members shared practical insights, including one doctor's explanation that Lyrica can cause fluid retention requiring water pills, another member's discovery that Cymbalta triggered constant hunger that resolved after stopping the medication, and suggestions to check thyroid function as a possible contributing factor. A recurring theme was the difficult choice between managing pain effectively and dealing with unwanted weight gain, with members encouraging each other to weigh the benefits against side effects and offering solidarity in a frustrating situation many thought they were facing alone.