I had tried Lyrica without success, then was put on Neurontin without success, I have Ultram but hate to take it because it's a controlled substance...then I tried a new doc who put me on Neurontin (for the nerve pain) plus Duexis (for joint inflammation) plus Chlorzoxazone (for muscle spasms) and B12 for the fatigue, Inositol (a supplement for insomnia/anxiety, melatonin (for sleep), and a magnesium supplement for muscle spasms. The combination of all these helped a lot more than trying them singly. Hope that helps! Oh I also take Imipramine (for depression/pain) and a compounded estrogen/progesterone, and Ziac for blood pressure.

Hydrotherapy has been my only relieve for years.

I find the best treatment is sleep, and diet and exercise. But realistically I never get enough sleep, and I try and eat healthy and well exercise can be a challenge at best. So I use recreational treatments such as marijuana which in turn helps me sleep - but not so much with the healthy diet and exercise part. FML!

I daily eat Tumeric root (not powdered) and endeavour to stay active as much as possible. Hydrotherapy has been wonderful and I go twice a week.

I also tried Lyrica without success.nuerontin also.