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Real members of MyFibroTeam have posted questions and answers that support our community guidelines, and should not be taken as medical advice. Looking for the latest medically reviewed content by doctors and experts? Visit our resource section.
A MyFibroTeam Member asked a question 💭
Waco, TX

My doctor has always mentioned putting me on Lyrica or Cymbalta. I read that they are both anti-depressants. I have a bad history with anti-depressants concerning their side effects. Many of them made me crazier or more depressed. I even had hallucinations with one of them. So I am very hesitant to even think about trying another. i'm just wondering how bad the side effects are with these, if they even work on the pain of fibromyalgia, and which of the two ya'll prefer. I just don't… read more

February 5, 2016 (edited)
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Answer Summary

Members shared mixed experiences with Lyrica and Cymbalta for fibromyalgia pain, with some finding Cymbalta most helpful while others... Read more

Members shared mixed experiences with Lyrica and Cymbalta for fibromyalgia pain, with some finding Cymbalta most helpful while others experienced troubling side effects like suicidal thoughts, increased depression, or withdrawal challenges that led them to stop. Several members preferred Lyrica for nerve pain relief without major side effects beyond dry mouth, though one noted it only helped for about a year, and concerns about weight gain were common. A recurring theme was the importance of carefully researching these medications before starting them and working closely with a doctor, as individual responses varied widely from life-changing relief to worsening symptoms.

A MyFibroTeam Member

Lyrica has not given me side effects but it certainly helps the pain. I cannot function without it. I tried cymbals but it MADE me depressed and anxious.

February 6, 2016 (edited)
A MyFibroTeam Member

Lyrica only helps for about a year.

February 6, 2016 (edited)
A MyFibroTeam Member

I'm on both medications the only side effect I've noticed is dry mouth nose and eyes. I still have pain

February 6, 2016
A MyFibroTeam Member

Lyrics is not an antidepressant. Cymbalta is an antidepressant. Lyrics helps with nerve pain. I am taking 50 mg in am and 100 mg at night. I did take cymbalta last year and it helped !y pain but then I started with suicidal thoughts and had to get off of it. I now take celexa 40 mg (antidepressant). Also take one flexeril at night with the lyrics. Flexeril is a muscle relaxer. I also take tramadal 50 mg for pain as needed.

February 5, 2016 (edited)
A MyFibroTeam Member

Cymbalta has by far been the best of all my medications for fibromyalgia. It really helped xx

February 5, 2016 (edited)

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