I take D-Ribose everyday and I've noticed a huge difference. I had itchy legs for the past 10+ years, I tried everything from changing laundry detergent, allergy shots even went as far as an allergy test because nothing was working. After I was diagnosed with fibro, my doc had me start ribose, within a week the itchiness went away!! I still get itchy during a flare but for the most part it's tolerable now. Muscle pains have gotten less intense and flares farther apart. I'm looking into more natural treatments to add but this is one that has worked for me so far.