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I have not taken this medication yet as I already take Pregabalin 150mg 2x a day and Mirtazapine 15mg at night and am a little concerned about adding another med. I would take this medication for both depression and fibro.

Thank you everyone :)

April 20, 2020
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Answer Summary

Members shared mixed but largely positive experiences with Bupropion for depression and fibromyalgia, with many reporting that it helped lift... Read more

Members shared mixed but largely positive experiences with Bupropion for depression and fibromyalgia, with many reporting that it helped lift their mood and several noting significant pain reduction, including one member whose pain dropped by nearly half. Several members mentioned important considerations, including potential side effects like leg weakness, brain zaps during withdrawal, and the risk of mood changes or agitation in some individuals, while others emphasized the importance of consulting doctors and pharmacists about drug interactions and monitoring for serotonin syndrome. A recurring theme was that individual responses vary widely, with some finding it life-changing and others experiencing no benefit or needing to discontinue due to side effects, reinforcing the value of careful trial under medical supervision.

A MyFibroTeam Member

I take Wellbutrin daily. My dose is fairly high because that is what my doctor found necessary to help me limit the deep depressive phases I go through (when my mood dips it tends to get stuck at the bottom and suicidal thoughts are not uncommon for me during those times). I am very prone to side effects so did have some during the initial use of this med which I expected. They eased up after the first couple weeks and are now unnoticeable. Wellbutrin has been the only antidepressant I have tried (among many) that worked for me more than 9-10 months. My doctor tried it partly because of its ability to reduce pain in fibromyalgia patients. I’m so glad he did as it reduced my pain by nearly half almost immediately. I haven’t returned to the pain levels I was at before I started the Wellbutrin except during flares and major weather changes. Hope this helps. Take care.

April 21, 2020
A MyFibroTeam Member

I tried wellbutrin many years ago but it threw me into reumatoid arthritis. It was so painful. The dr said he had bever seen that happen before. Obviously I quit taking it. I hope it works for you.

April 21, 2020
A MyFibroTeam Member

Wellbutrin is in the antidepressant category but was used extensively to help with stopping to smoke. It it's in it's own category. I took it years ago to quit smoking and I felt like the lights came on for the first time in my life and have been on it since. It also gives me a little energy. It raise your dopamine and norepinephrine catecholamines. Norepinephrine helps with pain relief, which is why cymbalta and savella are commonly used for Fibro, both affect an increase in norepinephrine.
Many people can feel suicidal, and very suddenly, if they have their dopamine levels raised too much. So obviously that is not the medication you need. I have several friends who responded similarly.

April 26, 2020
A MyFibroTeam Member

To Matt 2877, I take Bupropion 1x per day. This is the generic for Wellbutrin. Checked the side effects from Wellbutrin mind altering is not one of them. Please check with your Professional Doctor for dosage and side effect's. Everyone is different and do not respond to medication's the same.

April 20, 2020
A MyFibroTeam Member

Yes it’s just called gaba supplement. Be careful what you take with meds since it can cause serotonin problems. So ask your doctor or look up interference with herbs and meds. Natural might not help severe depression. I still struggle but I got tired of side effects. Of course sunshine and light exercise helps as well. It’s a hard life isn’t it, ughh! Hang in there! I feel your pain!!

April 20, 2020 (edited)

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