Cymbalta for depression/anxiety for fibro folk, plus Lyrica for nerve pain, Ambien for sleep along with a pain killer either an Nsaid or an opioid. The latter 2 are all that's available for pain. Those are the ones recommended for fibro. I'd like to suggest you see doctors who can see you at least once a month, and the shrink once a week or see a therapist who are the best people who can help you cope with fibro and the mess it's made of you entire life to say nothing of the people around you who are also driving you nuts. I take St John's Wort, in addition to Cymbalta. It's an over the counter anti-depressant you can get at your health food store. Wort means herb, btw. St Johns Wort is a European herb long used as an anti-depressant. I take 2 pills a day. I take caffeine tablets it I want to get anything done that day. Caffeine is a pain killer. No matter how bad you feel you have to be an advocate for your health. Complacency kills. Just because a doctor says it doesn't mean he or she knows what she's/he's talking about. The best place to find good doctors who are up on the latest meds and techniques is a teaching hospital. Look for pain clinics, and pain doctors. Research has determined that fibro is the result of damage to the central nervous system and brain. Your pain is real because your nerves are causing all your pain whether of not you have another problem so you may be in the best of health according to your doctors evaluation but your nerves are firing extraneous signals which you brain interprets as pain. Your pain is real and debilitating, your depression is dangerous as hell, your anxiety is driving you crazy, you can't sleep because your REM cycle is disrupted and you aren't getting to the restorative sleep you need to not feel fatigued all the time. You have problems planning, understanding, and resolving problems due to the brain damage you sustained because of an accident or horrific, as yet unknown illness. Insist on good care. You can feel better and better manage your condition. Don't be nice, be effective.

Cymbalta has helped me tremendously!

Their isn't a best anti-depressant. Each person is unique with a different chemistry. And there's all kinds of anti-depressants from mood stabilizers like lithium, to MAO inhibitors, to tricyclic anti-depressants, and Serotonin reuptake inhibitors. The first kind are taken by people with bipolar disorder, the next two kinds are older classes of drugs still in use for some with clinical depression, and the last kind are the ones made famous by Prozac, as well as Paxil, sertraline, and many others. Also, many anti-seizure drugs have been used as mood stabilizers, anti-depressants, and the latter has been used in pain management. I've found over the years of taking a varied cocktail of drugs for my mood disorder, that a lot of drugs have cross purposes. So far, none of my anti-depressants have reduced pain, though some I take have reduced pain for other people. I have gotten most of my information because I used to work as a mental health counselor.

I’m one of those people who can’t tolerate SSRIs, I suffer from extreme anxiety & agitation as well as insomnia. Old school works best. I take Trazodone which for me is a win-win as I sleep great which helps me cope with the pain better & I get an antidepressant effect so I feel more like myself & resilient. I think I’m pretty atypical. Cymbalta was the worst but I know many people really like it. This is just my own experience, not advice or recommendation.

I use Cymbalta and I've added St John's Wort which helps a lot. I find that my mood is brighter if I take 2 capsules a day. St John's Wort is a European herb that has been in use for ages. It's a natural anti-depressant and I've never heard anything not positive about it. I take caffeine capsules also because caffeine is good for pain and it provides an added lift. I take these in the morning so my sleep isn't affected. I've been diagnosed with Seasonal Affective Disorder, a condition brought on by the lack of sunlight in the Fall and Winter months. A half hour with a full spectrum light or 20 minutes in a tanning bed is said to mitigate the winter blues. The condition was first documented in New York City and then also found in people who winter over at the poles. It was found not only seasonal depression but weight gain of 35 pounds on average. Laughter also helps so keep your favorite comedies handy. :-)