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A MyFibroTeam Member asked a question 💭
Oxford, UK

Have been advised by my doctor to try Duloxetine, only in a small dose to help with my Fibro pain.

Im willing to give it a go but am a bit wary after all the bad side effects I have got off previous medication (gabapentin, pregabalin, amatrypaline)
I seem to be very sensitive to the side effects especially with my mental health being very fragile too.

I was wondering what other have thought of the affects of Duloxetine, has it helped?

January 25, 2017
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Answer Summary

Members shared mixed experiences with Duloxetine for fibromyalgia pain, with some finding it genuinely helpful for both pain and depression... Read more

Members shared mixed experiences with Duloxetine for fibromyalgia pain, with some finding it genuinely helpful for both pain and depression while others experienced minimal relief or troubling side effects. Several members described serious concerns including increased fatigue, brain fog, tremors, insomnia, stomach issues, and difficult withdrawal symptoms, with many emphasizing the importance of researching the medication thoroughly before starting and communicating immediately with doctors if something feels wrong. A recurring theme was the reality that fibromyalgia treatment remains a frustrating guessing game, with each person's body responding differently, yet the community offered solidarity and practical advice about managing side effects and advocating for oneself with medical providers.

A MyFibroTeam Member

@A MyFibroTeam Member just remember once you start taking it
If it doesn't feel right, tell your dr you need to stop right away. It takes about 3 weeks to fully get in your system.
I was put on cymbalta in hopes of a prayer, anything. I was desperate. I just wanted my life without pain. It was ok in the beginning but does absolutely nothing now. I've tried to go off of it but it is horrible!
Please research more.
It is not worth it😲

February 9, 2017
A MyFibroTeam Member

Please anyone suffering with side effects consider the medication called PROCYCLIDINE which can counter effect some side effects . Don't let these doctors not appreciate our unseen suffering like I am with my doctors neglect. I had to do three days of intense study to self diagnose with FM They are not educated about this syndrome enough , its quite apparent.
Take care all of you
You aren't alone

January 29, 2017
A MyFibroTeam Member

Yes everyone is different. I've heard it has helped a lot of people. But there are also horrible reviews on it here: https://ssristories.org/problems-with-cymbalta-...

I just stopped it last night because it made me have much worse insomnia and horrible stomach pains. I think it caused me to have acid reflux. It doesn't help with my pain. But it did take away my nausuea and dizziness. The first night I stopped the pill I slept mostly the whole night!:)

January 26, 2017 (edited)
A MyFibroTeam Member

Hi, I was on Cymbalta about 3 months and did not react well to it. It took about 2 weeks, then I started feeling strange, zombie-like... more tired than I already was, and not myself. I had to wean off & onto a different medication. I'm sure it may work for some people, but I had the same reaction to Lyrica and Effexor. Best of luck to you. Susan 💕

January 25, 2017
A MyFibroTeam Member

Been on it since October 2016, was just upped in my dosage two weeks ago and I can't say that it has dun anything to help with the pain on any level. Only thing it has dun is to force me to use foods that I've avoided for years because of the side effects it gives me I now NEED to have just to be regular which isn't great nor fun.

Also I am always fripping tired where before being on it I was almost never tired, I would wake up with only and hours sleep and be wide awake without feeling the need to go back to bed, that isn't the case anymore.

I'm not sure if I'll continue with it if at 60 mg it isn't helping with the pain since that it the only thing its needed for and it was about my last option out there to even give a little bit of relief and so far 0 effect, i'm starting to louse hope that I'll ever have a pain level under 5 ever again.

January 25, 2017

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