Yes, I have had RLS and PLMD. My legs twitch and jerk so I have to take a muscle relaxer

yep i have RLS too i need to take a pill once a day
or i'll be standing all night

Check the side effects of your meds. I had two that caused this.

Yes, I twitch and jerk unexpectedly. Not a lot but definetly more at night when I am trying to wind down. I have no idea what to do about it. This was actually happening BEFORE I was afflicted with 24/7 pain, when I was younger and healthier.