NRF2, Oxidative Stress and Fibromyalgia:

There are published studies on Pubmed showing the linkage between Fybromyalgia and Oxidative stress.

One in particular caught my eye. It is entitled, “Clinical symptoms in fibromyalgia are better associated to lipid peroxidation levels in blood mononuclear cells rather than in plasma.”

The researchers found increased oxidative stress as measured through Lipid peroxidation (LPO) levels in Fibromyalgia patients as compared to normal control group.

While one cannot claim that increasing NRF2 activation will cure any disease, there may be a case to test/experiment how your body reacts to different NRF2 activators and see what impact it has on your Fibromyalgia symptoms. We cite the following two reasons this course may be beneficial.

Firstly, NRF2 activation has been shown to reduce oxidative stress as measured through LPO, and secondly, there are studies showing the beneficial effects of NRF2 on inflammation. Current treatments of Fibromyalgia do include prescribing anti-inflammatory and muscle relaxant drugs.

It is important to remember that FM has been found to be neuro-muscular and not inflammation based like arthritis and other inflammatory pain markers.

My doctor has a rule of thumb as long as I run supplements by him and the supplement has been researched significantly - based on "research journals" and it is affordable and it helps then do it.

What is it?

No I have not used them. Some times I'm unable to that supplements when I have difficulty digesting them.