www.lowdosenaltrexone.org has an impressive amount of material if you are interested in looking deeper into the dosage, studies, and providers. They also have a printable info sheet to give to your physician.

LDN may only have smallish studies to back up its use in fibro, but for other disorders like MS which shares some symptomology with fibro, it has been demonstrated as very effective in medium sized trials (several hundred patients). Younger actually just hosted a digital seminar about his work at his new clinic, you can find it online the edited version. He and his team seem very dedicated. Cymbalta, savella, and lyrica all have pretty bad track records in clinical trials, they are barely more effective than placebo unless they really work for you (only like 10% in the trials had this effect). I haven't tried ldn yet but I am considering pursuing a teleconferance with a perscriber in new york if mh insurance will cover it. You can find more info through good old google and "ldn for fibromyalgia" type searchs

I'm not on it, but I've read all the research on it. There is one big, huge caveat I feel it necessary to give about LDN: the scientific evidence is unfortunately weak. It's based on two studies from Dr. Jared Younger when he was at Stanford (he's now at the Alabama Sleep Disorder's Center, I believe). The studies were on less then 100 total people. That said, the clinical experience of many doctors treating Fibro has been pretty positive. Dr. Ginerva Liptan in Oregon is a huge, vocal, proponent of it.

All of that said, the science is sound. Many Fibromites are getting relief from it. And, most importantly, it appears to be incredibly safe with a low incidence of side effects in doses given for Fibro.

@A MyFibroTeam Member That's actually a much higher dose than needed for Fibro on Cymbalta. All the clinical trials showed a 60mg dose was sufficient, with no increase in dose mediated efficacy above that, and a significant increase in side effects. Basically what I'm saying is, if there was going to be an effect on your Fibro, you should have felt it by now, definitely time to try something else.

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A MyFibro...

I started taking it about two months ago. It does help with the pain. I would not say its a huge difference but noticeable.