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A MyFibroTeam Member asked a question 💭
Harlow, UK

Do you take certain painkillers and after a week or so get use to them and feel pain again

August 30, 2015
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Answer Summary

Members shared their frustrations about painkillers like tramadol, morphine patches, and gabapentin losing effectiveness over time, with many... Read more

Members shared their frustrations about painkillers like tramadol, morphine patches, and gabapentin losing effectiveness over time, with many experiencing tolerance within weeks or months despite trying numerous medication combinations. Several members described their personal 'cocktails' that provided some relief, including combinations of Cymbalta, Lyrica, amitriptyline for sleep and restless legs, tonic water with quinine for leg symptoms, and alternative treatments like medical cannabis and ketamine infusions. A recurring theme was the exhausting cycle of finding medications that work temporarily before building tolerance, the difficulty of getting doctors to adjust treatment plans, and the additional burden of managing severe side effects while still living with uncontrolled pain.

A MyFibroTeam Member

It seems like it takes a different "cocktail" of drugs for each of us to feel any relief, and it is also constantly changing. I don't think pain pills like Tramadol or Norco would do much good on their own without at least some Cymbalta, Lyrica, Gabapentin, or Savella. They had me on Cymbalta, Lyrica, and Savella, with Tramadol and Flexeril AND ambien. Then, we changed it to Cymbalta, Lyrica, Norco, Norflex, and Nortriptyline for sleep. At the moment this will help me get by, but only when I am being sedentary. However, if I try to hold off on the Norco, man oh man I can feel the pain! :( Plus, dealing with the side effects of these meds are almost as bad as the pain and fatigue!! Keep working with your team of Drs, KEEP A JOURNAL documenting your pain levels, what activities you could or couldn't do, side effects, and even what you ate. This is very helpful for the Drs to have, when needed. Gentle HUGS, and God Bless!

August 30, 2015
A MyFibroTeam Member

Try drinking a can of Tonic water at bed time not the diet one but the ones that contain Quinine it helps a little,
also certain meds make my restless legs worse I can't take Tylenol or cold medications that have any sleep aids in them I'm on clonazepam 0.5 mgs that helps me sleep without making my restless legs worse, good thing about Tonic water is that it has no side effects long as you don't put Gin in it LOL

August 30, 2015
A MyFibroTeam Member

It's a vicious circle we are in got to say only good thing about amitriptlylin he helps with my Restless legs at night and also helps with my insomnia Dr wanted to do a 2 in 1 as it's an anti d 2 so hoping to pick up my mood which when I'm feeling fustrated in pain like this nothing seems to help :( thanks both for reply x

August 30, 2015
A MyFibroTeam Member

Hi Elsie I am so lucky that pot is legal here it has help me a lot I only take it on the really bad days otherwise it's not so effective, some times it gives me the giggles I laugh so hard it hurts and for that short while I'm forgetting my pain, as for standing on a street corner I'm not so sure you never know what's it's mixed with nowadays However I also have a prescription for Nabilone you may want to Google that it is a derivitive of canibis and has a similar effect

August 31, 2015
A MyFibroTeam Member

i am starting to think the same thing....nothing seems to be working

August 31, 2015

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