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November 28, 2025
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Answer Summary

Members shared mixed experiences with Duloxetine for fibromyalgia pain, with some finding it significantly reduced stiffness and helped with... Read more

Members shared mixed experiences with Duloxetine for fibromyalgia pain, with some finding it significantly reduced stiffness and helped with overall pain management while others reported it worked initially but lost effectiveness over time or caused uncomfortable side effects like heart pounding, nausea, and headaches. Several members emphasized the importance of giving the medication 6-12 weeks to work through initial adjustment periods, with practical strategies including pairing it with muscle relaxers like Flexeril or cyclobenzaprine, incorporating regular walking or exercise, and carefully monitoring symptoms without obsessing. A recurring theme was that finding the right medication is deeply personal and often requires trial and error, with many members encouraging faith, self-advocacy, listening to your body's limits, and working closely with doctors to find a treatment plan that works for your unique needs.

A MyFibroTeam Member

Good Morning 😃 I tried everything in the beginning,I just needed to get myself fixed to I go work at my job, I only can say on my end that those just side effects made me worse, those scary and horrible, all of the medications I tried in the past were just horrible that I just couldn’t do it and stop everything, but like I said, everyone is different. It’s been 13 years since my life style changed, I’m now at a whole new place, I rest more and differently watched what I eat. Once a week I have a cheat day 🥰 I always try to be careful avoiding stress and It’s gotten so much better having my Faith on God! I stop every time I feel am overwhelmed and say to myself Ok 👍🏻 that enough, rest now, because if I don’t listen to that inner voice, it will knock me out for a long time, that’s me. Every one is different but I told my self am not the same woman I was before, so I’m done now, I listen to that little voice, which is my Jesus, he’s been so good to me, am at peace with myself now, I pray for you all, all the time because it’s a battle but the battle belongs to the Lord. Have a Blessed Day 💜💜💜

January 14
A MyFibroTeam Member

It's the first and main pain medication I've been on. It takes time for the side effects to subside but I don't get the stiffness half as bad and it does help alot with the most pain. I have to take medication for my neck pain but that's arthritis

November 28, 2025
A MyFibroTeam Member

I take it. It can dull the pain but I don't think anything can render a response of no pain. Have been taking it for about 2 years now give or take. It is accompanied by cyclopenzeprine, a muscle relaxer. This helps my pain because my muscles tense up as well, along with seizures.
When it comes to medication, its a hit or miss thing; just got to try until you find what works for you.
I recently read that fibromyalgia is thought to be a different type of auto immune, the theory is that our immune systems attack our nerves. Unlike other conditions classified by this that your immune system attacks in other ways.
Science is still searching and I am happy that medicine is still searching for the cause.

January 14
A MyFibroTeam Member

I was on it and I got more side affects then it helped then my DR lowed the dose and still did the same thing so he took me off of it

December 2, 2025
A MyFibroTeam Member

Yes I take that and in my experience it has been working well. My Cymbalta 60 mg 1ce a day, I also experience seizures, for this I take cyclobenzeprine..
I have been taking Cymbalta for about a year now and have had fibromyalgia about 44 years now. It has worked best for my symptoms out of all the medications over the years. Remember to discuss its effects on your symptoms to ensure you have a treatment plan best suited to your needs.

November 28, 2025

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