fibromyalgia a auto immune disease. stress can cause it to. to much stress over time. auto immune diseases, caused by overactive immune system. i am on skyrizi for soriasis soriatic arthritis. u want a immune system in the middle. not overactive or weak immune system, either. it a pain in the butt. overactive immune system causes digestion problems. i hear it causes depression. it can make u hot out of nowhere. always tired. weak. gain weight. it can make u angry and have mood swings. a overactive immune system does all that. i dont remember in schools. that they taught overactive immune system. i had to research it on yahoo.