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Real members of MyFibroTeam have posted questions and answers that support our community guidelines, and should not be taken as medical advice. Looking for the latest medically reviewed content by doctors and experts? Visit our resource section.

Amitriptyline And Cymbalta Together. Iam On 30 Mg Of Amitriptyline And 20 Mg Of Duloxotine . Anyone Else On These 2 Meds?

A MyFibroTeam Member asked a question 💭
Sunnyvale, CA

I’ll go up to 40 mg of Duloxotine in a week.

May 4, 2019
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A MyFibroTeam Member

I am on 30 mg of Cymbalta and 25 mg of Amitriptyline. Doc might bump it up to 5o.

May 4, 2019 (edited)
A MyFibroTeam Member

I take 25 mg amitrptyline at night as needed. I also take CBD during the day..

May 5, 2019
A MyFibroTeam Member

Please ask your doctor about this (or the pharmacist), it doesn't take much to trigger it. It is better to know what it is since the treatment is the ER. My intention is not to cause fear. I experienced a drug interaction that resulted in 3 hospital stays.
Drug Interaction Report
This report displays the potential drug interactions for the following 2 drugs:
Applies to: amitriptyline, Cymbalta (duloxetine)

Using amitriptyline together with DULoxetine can increase the risk of a rare but serious condition called the serotonin syndrome,

February 12, 2020
A MyFibroTeam Member

I take a similar Rx to amitriptyline, it's nortriptyline, I take 75mg. This has helped my nerve pain in my feet and legs and also my headaches. I started with 30mg of Cymbalta, but it made me too, too hot and dripping sweat from my head and neck. Very embarrassing and annoying. Dr cut it down to 20mg which is more manageable. I sweat too much still in the summer. So I take it every other day in the summertime and back to every day in the fall, winter & spring. It is the main reason that I CAN get out of bed and live in the world.

May 8, 2019
A MyFibroTeam Member

My doctor tried. But, I couldn't do it. Left me lethargic
God bless you, with all of your meds.

May 4, 2019 (edited)

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