I was on Savella and definitely did not like how I felt! Very stressed and full of like rage lol it was weird.

I have been taking naltrexone for about 6 weeks. The pain management doctor said I should notice pretty quick if it was helping. I think it is taking the edge off. One of the side effects can be weight loss.

I tried it several times but could not tolerate it. I made my anxiety go thru the roof and gave me severe diarrhea.

I don't know if the Naltrexone is working or if it is a combination of other factors that have made me feel better. I still have achy joints with changes in the weather, but I am probably also developing arthritis, so I don't count that against the Naltrexone. I have been feeling better, but I still have some tender spots that are really sore and annoying. I am going to keep trying it for another month. I would really like to have something that I could tell was improving my pain.

Yes, I took it for probably at lease 6 months. I never noticed a difference. I have fibro, but was prescribed it for an undiagnosed autoimmune disease. It was expensive and I was already on so many medications, so I decided I needed to wean off of some of them. I chose that with my dr's consent.