I have been on Cymbalta for a few years. Having tried other meds supposedly for fibro, and experiencing adverse reactions but no help, this is what we settle on. We have 'played' with different dosages. I'm on 60 mg and about to go to 90mg (again). I cannot say conclusively that I have any positive help from Cymbalta as far as my fibro pain is concerned. It's difficult for me because I've had 6 various spinal surgeries which keep me in consistent pain. I take Viibryd to assist the depression. I take minimal doses of hydrocodone/acetaminophine for back pain. I can usually tell the difference between the back pain and a fibro flare. However, since I am in constant pain, my doc allows me to take what I need as I need it. I do not take even close the dosage I'm prescribed. I dislike drugs and would rather tough out the pain whenever possible. Don't know if my answer will be helpful to anyone. We are all so similar in many ways, yet when it comes to treatments, we all respond differently. Maybe someday some brilliant medical professional will discover the magic formula for help.